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Jan 8

Revisiting End-to-End Learning with Slide-level Supervision in Computational Pathology

Pre-trained encoders for offline feature extraction followed by multiple instance learning (MIL) aggregators have become the dominant paradigm in computational pathology (CPath), benefiting cancer diagnosis and prognosis. However, performance limitations arise from the absence of encoder fine-tuning for downstream tasks and disjoint optimization with MIL. While slide-level supervised end-to-end (E2E) learning is an intuitive solution to this issue, it faces challenges such as high computational demands and suboptimal results. These limitations motivate us to revisit E2E learning. We argue that prior work neglects inherent E2E optimization challenges, leading to performance disparities compared to traditional two-stage methods. In this paper, we pioneer the elucidation of optimization challenge caused by sparse-attention MIL and propose a novel MIL called ABMILX. It mitigates this problem through global correlation-based attention refinement and multi-head mechanisms. With the efficient multi-scale random patch sampling strategy, an E2E trained ResNet with ABMILX surpasses SOTA foundation models under the two-stage paradigm across multiple challenging benchmarks, while remaining computationally efficient (<10 RTX3090 hours). We show the potential of E2E learning in CPath and calls for greater research focus in this area. The code is https://github.com/DearCaat/E2E-WSI-ABMILX.

  • 7 authors
·
Jun 2, 2025 1

One Patch to Caption Them All: A Unified Zero-Shot Captioning Framework

Zero-shot captioners are recently proposed models that utilize common-space vision-language representations to caption images without relying on paired image-text data. To caption an image, they proceed by textually decoding a text-aligned image feature, but they limit their scope to global representations and whole-image captions. We present , a unified framework for zero-shot captioning that shifts from an image-centric to a patch-centric paradigm, enabling the captioning of arbitrary regions without the need of region-level supervision. Instead of relying on global image representations, we treat individual patches as atomic captioning units and aggregate them to describe arbitrary regions, from single patches to non-contiguous areas and entire images. We analyze the key ingredients that enable current latent captioners to work in our novel proposed framework. Experiments demonstrate that backbones producing meaningful, dense visual features, such as DINO, are key to achieving state-of-the-art performance in multiple region-based captioning tasks. Compared to other baselines and state-of-the-art competitors, our models achieve better performance on zero-shot dense, region-set, and a newly introduced trace captioning task, highlighting the effectiveness of patch-wise semantic representations for scalable caption generation. Project page at https://paciosoft.com/Patch-ioner/ .

  • 6 authors
·
Oct 3, 2025 2

FarSLIP: Discovering Effective CLIP Adaptation for Fine-Grained Remote Sensing Understanding

As CLIP's global alignment limits its ability to capture fine-grained details, recent efforts have focused on enhancing its region-text alignment. However, current remote sensing (RS)-specific CLIP variants still inherit this limited spatial awareness. We identify two key limitations behind this: (1) current RS image-text datasets generate global captions from object-level labels, leaving the original object-level supervision underutilized; (2) despite the success of region-text alignment methods in general domain, their direct application to RS data often leads to performance degradation. To address these, we construct the first multi-granularity RS image-text dataset, MGRS-200k, featuring rich object-level textual supervision for RS region-category alignment. We further investigate existing fine-grained CLIP tuning strategies and find that current explicit region-text alignment methods, whether in a direct or indirect way, underperform due to severe degradation of CLIP's semantic coherence. Building on these, we propose FarSLIP, a Fine-grained Aligned RS Language-Image Pretraining framework. Rather than the commonly used patch-to-CLS self-distillation, FarSLIP employs patch-to-patch distillation to align local and global visual cues, which improves feature discriminability while preserving semantic coherence. Additionally, to effectively utilize region-text supervision, it employs simple CLS token-based region-category alignment rather than explicit patch-level alignment, further enhancing spatial awareness. FarSLIP features improved fine-grained vision-language alignment in RS domain and sets a new state of the art not only on RS open-vocabulary semantic segmentation, but also on image-level tasks such as zero-shot classification and image-text retrieval. Our dataset, code, and models are available at https://github.com/NJU-LHRS/FarSLIP.

  • 7 authors
·
Nov 18, 2025

Image Labels Are All You Need for Coarse Seagrass Segmentation

Seagrass meadows serve as critical carbon sinks, but accurately estimating the amount of carbon they store requires knowledge of the seagrass species present. Using underwater and surface vehicles equipped with machine learning algorithms can help to accurately estimate the composition and extent of seagrass meadows at scale. However, previous approaches for seagrass detection and classification have required full supervision from patch-level labels. In this paper, we reframe seagrass classification as a weakly supervised coarse segmentation problem where image-level labels are used during training (25 times fewer labels compared to patch-level labeling) and patch-level outputs are obtained at inference time. To this end, we introduce SeaFeats, an architecture that uses unsupervised contrastive pretraining and feature similarity to separate background and seagrass patches, and SeaCLIP, a model that showcases the effectiveness of large language models as a supervisory signal in domain-specific applications. We demonstrate that an ensemble of SeaFeats and SeaCLIP leads to highly robust performance, with SeaCLIP conservatively predicting the background class to avoid false seagrass misclassifications in blurry or dark patches. Our method outperforms previous approaches that require patch-level labels on the multi-species 'DeepSeagrass' dataset by 6.8% (absolute) for the class-weighted F1 score, and by 12.1% (absolute) F1 score for seagrass presence/absence on the 'Global Wetlands' dataset. We also present two case studies for real-world deployment: outlier detection on the Global Wetlands dataset, and application of our method on imagery collected by FloatyBoat, an autonomous surface vehicle.

  • 5 authors
·
Mar 2, 2023

GUI-Actor: Coordinate-Free Visual Grounding for GUI Agents

One of the principal challenges in building VLM-powered GUI agents is visual grounding, i.e., localizing the appropriate screen region for action execution based on both the visual content and the textual plans. Most existing work formulates this as a text-based coordinate generation task. However, these approaches suffer from several limitations: weak spatial-semantic alignment, inability to handle ambiguous supervision targets, and a mismatch between the dense nature of screen coordinates and the coarse, patch-level granularity of visual features extracted by models like Vision Transformers. In this paper, we propose GUI-Actor, a VLM-based method for coordinate-free GUI grounding. At its core, GUI-Actor introduces an attention-based action head that learns to align a dedicated <ACTOR> token with all relevant visual patch tokens, enabling the model to propose one or more action regions in a single forward pass. In line with this, we further design a grounding verifier to evaluate and select the most plausible action region from the candidates proposed for action execution. Extensive experiments show that GUI-Actor outperforms prior state-of-the-art methods on multiple GUI action grounding benchmarks, with improved generalization to unseen screen resolutions and layouts. Notably, GUI-Actor-7B even surpasses UI-TARS-72B (38.1) on ScreenSpot-Pro, achieving scores of 40.7 with Qwen2-VL and 44.6 with Qwen2.5-VL as backbones. Furthermore, by incorporating the verifier, we find that fine-tuning only the newly introduced action head (~100M parameters for 7B model) while keeping the VLM backbone frozen is sufficient to achieve performance comparable to previous state-of-the-art models, highlighting that GUI-Actor can endow the underlying VLM with effective grounding capabilities without compromising its general-purpose strengths.

  • 18 authors
·
Jun 3, 2025 3

REGLUE Your Latents with Global and Local Semantics for Entangled Diffusion

Latent diffusion models (LDMs) achieve state-of-the-art image synthesis, yet their reconstruction-style denoising objective provides only indirect semantic supervision: high-level semantics emerge slowly, requiring longer training and limiting sample quality. Recent works inject semantics from Vision Foundation Models (VFMs) either externally via representation alignment or internally by jointly modeling only a narrow slice of VFM features inside the diffusion process, under-utilizing the rich, nonlinear, multi-layer spatial semantics available. We introduce REGLUE (Representation Entanglement with Global-Local Unified Encoding), a unified latent diffusion framework that jointly models (i) VAE image latents, (ii) compact local (patch-level) VFM semantics, and (iii) a global (image-level) [CLS] token within a single SiT backbone. A lightweight convolutional semantic compressor nonlinearly aggregates multi-layer VFM features into a low-dimensional, spatially structured representation, which is entangled with the VAE latents in the diffusion process. An external alignment loss further regularizes internal representations toward frozen VFM targets. On ImageNet 256x256, REGLUE consistently improves FID and accelerates convergence over SiT-B/2 and SiT-XL/2 baselines, as well as over REPA, ReDi, and REG. Extensive experiments show that (a) spatial VFM semantics are crucial, (b) non-linear compression is key to unlocking their full benefit, and (c) global tokens and external alignment act as complementary, lightweight enhancements within our global-local-latent joint modeling framework. The code is available at https://github.com/giorgospets/reglue .

  • 6 authors
·
Dec 18, 2025 2

MixReorg: Cross-Modal Mixed Patch Reorganization is a Good Mask Learner for Open-World Semantic Segmentation

Recently, semantic segmentation models trained with image-level text supervision have shown promising results in challenging open-world scenarios. However, these models still face difficulties in learning fine-grained semantic alignment at the pixel level and predicting accurate object masks. To address this issue, we propose MixReorg, a novel and straightforward pre-training paradigm for semantic segmentation that enhances a model's ability to reorganize patches mixed across images, exploring both local visual relevance and global semantic coherence. Our approach involves generating fine-grained patch-text pairs data by mixing image patches while preserving the correspondence between patches and text. The model is then trained to minimize the segmentation loss of the mixed images and the two contrastive losses of the original and restored features. With MixReorg as a mask learner, conventional text-supervised semantic segmentation models can achieve highly generalizable pixel-semantic alignment ability, which is crucial for open-world segmentation. After training with large-scale image-text data, MixReorg models can be applied directly to segment visual objects of arbitrary categories, without the need for further fine-tuning. Our proposed framework demonstrates strong performance on popular zero-shot semantic segmentation benchmarks, outperforming GroupViT by significant margins of 5.0%, 6.2%, 2.5%, and 3.4% mIoU on PASCAL VOC2012, PASCAL Context, MS COCO, and ADE20K, respectively.

  • 8 authors
·
Aug 9, 2023

Weakly Supervised Semantic Segmentation via Progressive Patch Learning

Most of the existing semantic segmentation approaches with image-level class labels as supervision, highly rely on the initial class activation map (CAM) generated from the standard classification network. In this paper, a novel "Progressive Patch Learning" approach is proposed to improve the local details extraction of the classification, producing the CAM better covering the whole object rather than only the most discriminative regions as in CAMs obtained in conventional classification models. "Patch Learning" destructs the feature maps into patches and independently processes each local patch in parallel before the final aggregation. Such a mechanism enforces the network to find weak information from the scattered discriminative local parts, achieving enhanced local details sensitivity. "Progressive Patch Learning" further extends the feature destruction and patch learning to multi-level granularities in a progressive manner. Cooperating with a multi-stage optimization strategy, such a "Progressive Patch Learning" mechanism implicitly provides the model with the feature extraction ability across different locality-granularities. As an alternative to the implicit multi-granularity progressive fusion approach, we additionally propose an explicit method to simultaneously fuse features from different granularities in a single model, further enhancing the CAM quality on the full object coverage. Our proposed method achieves outstanding performance on the PASCAL VOC 2012 dataset e.g., with 69.6$% mIoU on the test set), which surpasses most existing weakly supervised semantic segmentation methods. Code will be made publicly available here https://github.com/TyroneLi/PPL_WSSS.

  • 6 authors
·
Sep 16, 2022

RegionRAG: Region-level Retrieval-Augmented Generation for Visual Document Understanding

Multi-modal Retrieval-Augmented Generation (RAG) has become a critical method for empowering LLMs by leveraging candidate visual documents. However, current methods consider the entire document as the basic retrieval unit, introducing substantial irrelevant visual content in two ways: 1) Relevant documents often contain large regions unrelated to the query, diluting the focus on salient information; 2) Retrieving multiple documents to increase recall further introduces redundant and irrelevant documents. These redundant contexts distract the model's attention and further degrade the performance. To address this challenge, we propose RegionRAG, a novel framework that shifts the retrieval paradigm from the document level to the region level. During training, we design a hybrid supervision strategy from both labeled data and unlabeled data to pinpoint relevant patches. During inference, we propose a dynamic pipeline that intelligently groups salient patches into complete semantic regions. By delegating the task of identifying relevant regions to the retriever, RegionRAG enables the generator to focus solely on concise, query-relevant visual content, improving both efficiency and accuracy. Experiments on six benchmarks demonstrate that RegionRAG achieves state-of-the-art performance. It improves retrieval accuracy by 10.02% in R@1 on average, and boosts question answering accuracy by 3.56% while using only 71.42% visual tokens compared with prior methods.

  • 6 authors
·
Oct 31, 2025

MM-PRM: Enhancing Multimodal Mathematical Reasoning with Scalable Step-Level Supervision

While Multimodal Large Language Models (MLLMs) have achieved impressive progress in vision-language understanding, they still struggle with complex multi-step reasoning, often producing logically inconsistent or partially correct solutions. A key limitation lies in the lack of fine-grained supervision over intermediate reasoning steps. To address this, we propose MM-PRM, a process reward model trained within a fully automated, scalable framework. We first build MM-Policy, a strong multimodal model trained on diverse mathematical reasoning data. Then, we construct MM-K12, a curated dataset of 10,000 multimodal math problems with verifiable answers, which serves as seed data. Leveraging a Monte Carlo Tree Search (MCTS)-based pipeline, we generate over 700k step-level annotations without human labeling. The resulting PRM is used to score candidate reasoning paths in the Best-of-N inference setup and achieves significant improvements across both in-domain (MM-K12 test set) and out-of-domain (OlympiadBench, MathVista, etc.) benchmarks. Further analysis confirms the effectiveness of soft labels, smaller learning rates, and path diversity in optimizing PRM performance. MM-PRM demonstrates that process supervision is a powerful tool for enhancing the logical robustness of multimodal reasoning systems. We release all our codes and data at https://github.com/ModalMinds/MM-PRM.

  • 7 authors
·
May 19, 2025 2

Enquire One's Parent and Child Before Decision: Fully Exploit Hierarchical Structure for Self-Supervised Taxonomy Expansion

Taxonomy is a hierarchically structured knowledge graph that plays a crucial role in machine intelligence. The taxonomy expansion task aims to find a position for a new term in an existing taxonomy to capture the emerging knowledge in the world and keep the taxonomy dynamically updated. Previous taxonomy expansion solutions neglect valuable information brought by the hierarchical structure and evaluate the correctness of merely an added edge, which downgrade the problem to node-pair scoring or mini-path classification. In this paper, we propose the Hierarchy Expansion Framework (HEF), which fully exploits the hierarchical structure's properties to maximize the coherence of expanded taxonomy. HEF makes use of taxonomy's hierarchical structure in multiple aspects: i) HEF utilizes subtrees containing most relevant nodes as self-supervision data for a complete comparison of parental and sibling relations; ii) HEF adopts a coherence modeling module to evaluate the coherence of a taxonomy's subtree by integrating hypernymy relation detection and several tree-exclusive features; iii) HEF introduces the Fitting Score for position selection, which explicitly evaluates both path and level selections and takes full advantage of parental relations to interchange information for disambiguation and self-correction. Extensive experiments show that by better exploiting the hierarchical structure and optimizing taxonomy's coherence, HEF vastly surpasses the prior state-of-the-art on three benchmark datasets by an average improvement of 46.7% in accuracy and 32.3% in mean reciprocal rank.

  • 5 authors
·
Jan 27, 2021

GroundedPRM: Tree-Guided and Fidelity-Aware Process Reward Modeling for Step-Level Reasoning

Process Reward Models (PRMs) aim to improve multi-step reasoning in Large Language Models (LLMs) by supervising intermediate steps and identifying errors. However, building effective PRMs remains challenging due to the lack of scalable, high-quality annotations. Existing approaches rely on costly human labeling, LLM-based self-evaluation that is prone to hallucination, or Monte Carlo (MC) estimation, which infers step quality solely from rollout outcomes and often introduces noisy, misaligned supervision due to credit misattribution. These issues result in three core limitations: noisy rewards, low factual fidelity, and misalignment with step-level reasoning objectives. To address these challenges, we introduce GroundedPRM, a tree-guided and fidelity-aware framework for automatic process supervision. To reduce reward noise and enable fine-grained credit assignment, we construct structured reasoning paths via Monte Carlo Tree Search (MCTS). To eliminate hallucinated supervision, we validate each intermediate step using an external tool, providing execution-grounded correctness signals. To combine both step-level validation and global outcome assessment, we design a hybrid reward aggregation mechanism that fuses tool-based verification with MCTS-derived feedback. Finally, we format the reward signal into a rationale-enhanced, generative structure to promote interpretability and compatibility with instruction-tuned LLMs. GroundedPRM is trained on only 40K automatically labeled samples, amounting to just 10% of the data used by the best-performing PRM trained with auto-labeled supervision. Nevertheless, it achieves up to a 26% relative improvement in average performance on ProcessBench. When used for reward-guided greedy search, GroundedPRM outperforms even PRMs trained with human-labeled supervision, offering a scalable and verifiable path toward high-quality process-level reasoning.